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Nature 443 , 590593 (2006)

Because of the anatomical arrangement of the liver and the pancreas, when insulin is released from the -cells of the pancreas into the portal circulation nearly 50% is captured (also referred to as extracted) by hepatocytes

doi:10.1186/1471-244x-14-s1-s1 Aggarwal R, Kunik M, Asghar-Ali A

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Among these, butyrate is the principal energy source for colonic epithelial cells, whereas acetate and propionate are essential for hepatic lipogenesis and gluconeogenesis (Rios-Covian et al., 2017)