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People experienced in e-cigarette use in a real-world environment using their own device can reach effective nicotine delivery profiles comparable to cigarette smoking 25 , but this may increase their e-cigarette dependence potential 49

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The primary outcomes of the trial are 5 key harm-reduction metrics: Change in cigarettes smoked per day, The percentage that complete lung cancer screening, Improvements in systolic blood pressure, Improvements in total cholesterol, and Improvements in an overall score of cardiovascular disease risk