glp-1 agonist gila monster venom… and weight loss? 🦎 It sounds wild, but it's true. medications were inspired by a hormone first discovered in the saliva of a Gila monster. On this week's Gila Monster Venom: The Unexpected

Sikiric P, Marovic A, Matoz W, Anic T, Buljat G, Mikus D, et al

Published 2021 Feb 11

Part of amylins postprandial glucagon suppression is not a wholly separate action but a downstream consequence of the gastric-emptying delay itself: when nutrients arrive in the intestine more slowly, the signals that would otherwise drive inappropriate glucagon release are themselves blunted

While the research is primarily from skin models (in vitro, animal, and some human topical studies), they point to GHK-Cu as a peptide that supports structural repair, which is more suitable for lifters coming off hard training or minor injuries but not for direct muscle growth [1, 2]

Dietary modifications can substantially improve tolerability and reduce gastroparesis risk

Liraglutide for weight management: a critical review of the evidence