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Given that PAR2-G37I mutation has no impact on fasted ghrelin or postprandial GLP-1 levels, the mechanism by which TMPRSS2 regulates GLP-1 is likely independent of canonical PAR2 cleavage by TMPRSS2
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Additionally, there was some heterogeneity in follow-up durations across the trials, ranging from week 52 to 72
Researchers say even rare risks like these may amount to hundreds of thousands of new cases
The idea is to strike a balance: provide enough of the medication to support appetite control and weight maintenance, decrease inflammation and address other issues, while reducing the likelihood of side effects
