AOD 9604 efficacy in clinical trials was modest at best
For example, in a new study, patients who first used a daily topical treatment gel containing 0.1% adapalene and 2.5% benzoyl peroxide for 2-4 weeks before undergoing 3 treatments with Sebacia, spaced 1-2 weeks apart, saw an improvement of 66% at 3 months, as compared to those who had Sebacia alone (in the clinical trials), and showed 49% improvement at 3 months
However, the inherent risks associated with Gram-negative bacteria, namely lipopolysaccharide endotoxicity and the potential for plasmid-mediated horizontal gene transfer, remain obstacles to its application in patients with cirrhosis or immunocompromised conditions
The goal is to introduce the water as gently as possible
However, more recent evidence suggests that these vascular changes are not the cause of migraine, but rather an epiphenomenon that accompanies the pain (Rizzoli 2012)
its a vital medical treatment that corrects an underlying deficiency
