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As progesterone fluctuates and gradually declines during perimenopause, sleep can become more fragmented and less restorative

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As part of the antioxidant defence system, GSH participates in conjugation reactions catalyzed by glutathione-S-transferases (GSTs), in the reduction of hydrogen peroxide (H O ) and lipid hydroperoxides (LOOH) catalyzed by glutathione peroxidases (Gpxs), and the reduction 2 2 of protein-disulfi des (PrSSG) catalyzed by glutaredoxins (Grxs)

Energy production and mitochondrial function A study published in the Journal of Nutritional Biochemistry examined niacinamide supplementation in obese subjects and found that it reprogrammed adipose cellular metabolism and increased mitochondrial biogenesis

Look for anti-inflammatory ingredients including glutathione, N-acetyl cysteine (NAC), alpha lipoic acid, vitamin C, and nicotinamide riboside (NR)