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Description

The first oral GLP-1 agonist drug approved by the FDA for type 2 diabetes and weight loss is oral semaglutide

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Previous studies have demonstrated that the cAMP/p-AMPK/p-ACC and insulin-sensitizing pathways are pivotal to GLP-1s beneficial effects on hepatic lipid metabolism

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Endogenous GLP1 is produced by cleavage of the prohormone proglucagon in the intestinal endocrine L cells and is released in response to food intake

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